Ayesha Takia was born on April 10, 1986 and grew up in Mumbai, Maharashtra. She comes from a mixed family. Her father, Nishit, is Gujarati, and her mother, Faridah, is half British and half Maharashtrian, an Anglo-Indian Muslim. Takia went to St. Anthony's High School, but never went to college because she started to work when she turned sixteen.
She appeared in the famous I'm a Complan Boy! I'm a Complan Girl! campaign alongside Shahid Kapoor and also in a music video, Falguni Pathak's Meri Chunar Udd Udd Jaye, when she was fifteen. She then appeared in the video, Shake It Daddy, when she was sixteen, which brought her to the attention of the movie industry, and a few film offers followed. She signed a contract for Socha Na Tha, then for Taarzan: The Wonder Car. However, delays in making Socha Na Tha meant that Taarzan released first and was therefore her "debut" film. She won the Filmfare Best Debut Award in 2004 for her performance in Taarzan: The Wonder Car